Degassing of Biotech Devices incorporating Custom Quality Products

Degassing of Biotech Devices incorporating Custom Quality Products
Degassing of Biotech Devices incorporating Custom Quality Products
A degassing system consists of a vacuum chamber, a vacuum pump, and vacuum pump connection hardware. Such system is used to remove entrapped gasses from a liquid. A biotech customer of ours contacted us to design, manufacture, and deliver a custom vacuum degassing system which included a custom tray, wire feedthroughs, and BNC Vacuum feedthroughs.

Due to being a cGMP facility, our customer had stringent requirements which had to follow strict FDA Guidelines. The degassing process had to be recorded, monitored, validated, and repeatable across batches. The system we provided for them was an acrylic vacuum chamber with 14 inch Inside dimensions. This was a fully assembled system – once they received this, all they had to do is plug it in, no additional assembly was necessary. The vacuum pump we provided to them was a piston pump. Although not ideal, since the maximum achievable vacuum is not as high as compared to the rotary vane vacuum pump, it was chosen due to the fact that a piston pump is an oil free pump and does not emit oil mist. Furthermore, an oil free pump will not have the risk of oil contamination thru product degassing. This was a table top chamber meaning only a vacuum pump and vacuum pump was provided.

The vacuum chamber customization included, a QTY: 3 x #14 Gauge wires, a QTY: 9 x #22 Gauge wires, QTY: 2 x BNC Coaxial Feedthrough, and a vacuum pump 0.25 inch NPT Feedthrough. Each feedthrough is fully vacuum sealed where they can be operated during full vacuum degassing operation without the loss of vacuum performance. A digital Vacuum gauge was also provided so that the degassing process can follow cGMP guidelines such as being recordable and reputable due to the fact that a digital vacuum gauge has a much higher accuracy and precision as compared to a dial vacuum gauge. If you are looking for a degassing system, please take a look at our vacuum degassing systems made by Sanatron. There are several standard systems available and we will be happy to customize these for you as per your requirements. Contact us for more information.

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Force Decay Leak Testing Systems
Force Decay Leak Testing Systems are instruments that detect and quantify leaks in a test specimen through measuring the drop in force an inflated specimen applied onto a pressure transducer. The specimen is placed into a vacuum chamber, a vacuum is pulled, and the test sample inflates. As the test sample inflates, it applied a specific force onto the force transducer. This force is measured and recorded over time. If a leak exists, the specimen will deflate and lose pressure, as a result, the force it applies onto the force transducer will decrease. This in turn will enable for detection and quantification of a leak in the specimen.
BNC Vacuum Feedthroughs
Coaxial Vacuum Feedthroughs are vacuum rated BNC connectors that enable you to run BNC from outside of vacuum chamber towards inside of the vacuum chamber without disturbing the vacuum. Triaxial Vacuum Feedthroughs, just like coax vacuum feedthroughs, will enable you to run Triax Connections from outside towards the inside of the vacuum chamber without disturbing the vacuum levels inside the vacuum chamber.
Our Work: High Altitude Vacuum Testing of Electrical Connectors and Components
This was an interesting project where one of our customers needed to test wires up to 44 inches long within a high altitude simulation environment. In addition to testing wires, several other electric connectors required altitude testing as well. The altitude requirements were 100,000 feet (30.510 km) which corresponds to 8.36 Torr - a piece of cake when it comes to the vacuum requirements of our chambers.
Related Articles: Selecting a Proper Vacuum Pump for your Acrylic Vacuum Chamber
In this article we will talk about Vacuum Pumps - but also about other equipment which is used to produce vacuum inside a closed system or chamber. We will talk about the workings of a vacuum pump, vacuum generation, pump down, pump horsepower. This article is intended to provide you a practical guide which should help you select the appropriate vacuum pump for your system.